Downstream Essentials: From Cell Harvest to Final Purification (Theory and Practical)

Level

Introductory

Format

Instructor-led, virtual (half day); on-site, practical (2 days)

Duration

2.5 days

Cost

$2,406

Overview

This course introduces participants to the key downstream operations in biopharmaceutical production. It combines lecture-based theory with hands-on practical training covering core topics such as harvest, ultrafiltration/diafiltration, viral clearance, and chromatography.

Participants first learn the fundamentals of filtration and chromatography in a classroom setting, then apply this knowledge during guided practical sessions that replicate real-world manufacturing processes.

Why It’s Essential

Downstream processing is complex and requires a thorough understanding of each unit operation to prevent issues that could affect product quality. This course teaches participants how to avoid common pitfalls and improve yield through practical, real-world applications—equipping downstream teams with the knowledge and confidence needed for success.

Learning Objectives

• Hands-on experience with key downstream unit operations including depth filtration, tangential flow filtration (TFF), virus clearance, and chromatography equipment

• Practical skills for identifying and troubleshooting yield losses caused by leaks, membrane fouling, and chromatography breakthrough to maintain process efficiency

Who Should Attend

• Laboratory technicians, scientists, process developers, operators, process engineers, manufacturing supervisors and QA professionals in the biopharmaceutical sector dealing with downstream processing unit operations.

Participants who successfully complete a theoretical assessment will receive a certificate of completion.